Clinical Analytics Platform Use Cases – Direct Patient Care and as a Research Platform

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Ambient Clinical Analytics (ACA), a Rochester, Minnesota-based company, sells AWARE, a real time clinical analytics platform with smart notification tools that reduce health care costs and improve patient outcomes. AWARE uses licensed Mayo Clinic technologies, that include over 1,200 proven rules and algorithms, to give critical care providers real-time access to vital point of-care information and analytics based smart notifications for conditions like Sepsis at the bedside. ACA clinical analytics platform has achieved FDA Class II Clearance, CE Marking, and ISO 13485:2016 Certification on the AWARE platform.

The AWARE clinical analytics platform has been utilized in clinical practice at Mayo Clinic since 2012 (US Patent #10,460,408). Our clinical analytics platform promotes situational awareness for patients in the acute care setting, and incorporates salient information displays, data analytics, context sensitive checklists and alerts (“smart checklists” and “smart alerts”), as well as reporting features to help clinicians track quality metrics in real time utilizing a single, integrated decision support system with high validity.

Clinical Analytics Platform Clinical Analytics Platform

AWARE. ICU floor situation awareness and patient room representation

AWARE's innovative dashboard and clinical decision support focuses on reducing information overload and makes it possible to prioritize clinically important information. Used by over a thousand clinicians across multiple hospitals, the AWARE implementations have been associated with marked improvement in clinical outcomes. Adjusted for illness severity, the odds for hospital mortality of critically ill patients treated after AWARE implementation were reduced by half (odds ratio 0.45, 95% confidence interval 0.30 to 0.70). In addition, the length of ICU stay decreased by 50%, length of hospital stay by 37%, and total charges for hospital stay by 30% ($43,745 per hospital admission) [1]. A series of peer-reviewed papers have been published demonstrating AWARE's efficacy as a clinical analytics system. [Example 2] AWARE has been fully integrated with Epic, Cerner, Allscripts and Meditech and it has been demonstrated in a civilian setting to lead to improvements in provider and team performance, system processes of care reliability, and reduced resource utilization.



AWARE has also been used as the primary clinical analytics platform for numerous research based projects including, a Center for Medical Services (CMS) innovation award that supported further development and validation of AWARE in diverse healthcare systems across the US, a DOD project for ICU improvement with an installation at Madigan Army Hospital, the development of a PMML shock algorithm with Applied Research Associates, the SCCM COVID-19 Data Registry project, and over 15 published research projects led by Mayo Clinic. The standard AWARE clinical analytics platform installation can be easily configured for any research project.

Based on previous studies on AWARE, using a human centered interface design for acute care practice, the research has shown improved processes of care, improved patient outcomes and reduced costs. Key outcomes that have been measured include:
  • Provider Level: cognitive load, safety culture, team communication, satisfaction, technology usage.
  • Level: Processes of care targets will be identified with local practice but may include items such as use of non-invasive and low tidal volume modes of ventilation , judicious fluid resuscitation and shock reversal, restricted blood product use, DVT prophylaxis, central device removal, goals of care discussion, and sepsis bundle of care compliance.
  • Patient level: ICU and overall hospital mortality (unadjusted and severity of illness adjusted), ICU and overall hospital length of stay, ventilator free days, discharge location.
  • Development of numerous algorithms covering all aspects of critical care.


Ambient Clinical Analytics provides the overall system integration and field deployment of the AWARE clinical analytics platform. Ambient has the development, system integration, field installation and support required for hospital and research projects. The AWARE platform of products has been installed and deployed in dozens of locations around the world. Ambient Clinical Analytics expertise includes regulatory skills in the SaMD category of Health IT products with FDA Class II Clearance, CE Marking, and ISO 13485 Registration.

Contact us today to learn more about how you can apply the AWARE clinical analytics platform to your health system.

1. Olchanski, N., et al., Can a Novel ICU Data Display Positively Affect Patient Outcomes and Save Lives? J Med Syst, 2017. 41(11): p. 171.
2. Pickering, B.W., et al., The implementation of clinician designed, human-centered electronic medical record viewer in the intensive care unit: a pilot step-wedge cluster randomized trial. Int J Med Inform, 2015. 84(5): p. 299-307.