Top 7 Sepsis Detection Solutions in 2026

Key Takeaways

Sepsis detection tools vary widely, from AI-based prediction to workflow automation.
FDA clearance and CE Mark certification remain key indicators of reliability.
Full Electronic Health Record (EHR) integration and compliance tracking are critical for hospital adoption.
Platforms like Ambient Sepsis DART™ combine detection, workflow, and compliance into a single system.

Introduction

Sepsis remains one of the most critical challenges in healthcare. Rapid detection and timely intervention are essential to improving outcomes and saving lives. As technology evolves, hospitals have more options than ever to support early recognition, clinical decision-making, and workflow automation.

However, not all sepsis detection solutions approach the problem the same way. Some focus on predictive AI algorithms. Others provide dashboards for patient monitoring or diagnostic tests that confirm sepsis after the fact. This comparison looks at the leading sepsis detection tools for 2026, what they do well, where they fall short, and how hospitals can find the right fit for their needs.

What Does This Guide Cover?

This overview compares the top sepsis detection technologies available today, focusing on four key areas that impact adoption and effectiveness:

Ease of implementation and clinician usability
FDA and CE regulatory certifications
Real-time bundle compliance tracking
Integration with hospital systems

Who Are the Leading Sepsis Detection Companies in 2026?

The sepsis detection landscape comprises a wide range of companies, from early-stage AI innovators to established healthcare technology providers. Each offers a unique approach, but many solutions still address only part of the problem of alerting clinicians to risk without guiding what happens next.

Below is a look at several major competitors and their approaches to detecting and managing sepsis:

Ambient Clinical Analytics

Developer of Sepsis DART™, a platform designed to detect potential sepsis and guide timely interventions directly within existing EHR workflows.
AWARE™, which includes Sepsis DART™, is FDA Class II cleared and CE Marking certified, indicating validated clinical reliability and regulatory compliance.
Emphasizes real-time bundle compliance tracking and workflow automation, supporting hospitals in meeting sepsis CMS quality measures and the correct care consistently.
Sepsis DART™ was specifically designed for detection and to drive the care process.

Bayesian Health

AI-driven company founded out of Johns Hopkins research.
Uses predictive algorithms to identify patients at risk for sepsis and other conditions through EHR data analysis.
Focus on early detection alerting. Integration into hospital EHR workflows and broader deployment are unknown.

Spacelabs Healthcare

Provides predictive analytics centered on the Rothman Index, a patient-acuity score that tracks physiological condition and deterioration.
FDA-cleared for general patient‐acuity alerting, including risk of decompensation. The algorithm was originally developed for decompensation in many cases can detect sepsis.
Emphasizes real-time visualization and early warning rather than full clinical workflow automation. Does not integrate workflows into the EHR

The EHR

Systems often include basic sepsis or deterioration alert modules based on SIRS within their standard clinical platforms.
Their primary strength lies in centralized documentation and data collection rather than specialized sepsis analytics. Using EHR’s to drive appropriate sepsis care over the last decade has not moved the need on adherence to the Sep-1 CMS bundle elements.
Hospitals frequently augment core EHR functionality with additional decision-support or compliance-tracking tools specifically designed for sepsis detection and management of care delivery.

Luminare

Specializes in software for early sepsis screening and workflow support.
Offers solutions that can operate as standalone tools or scale across enterprise environments. Does not integrate workflows into the EHR
Focuses on using clinical data and workflow integration to help teams act quickly and improve decision-making.

Prenosis

Offers a sepsis detection system, ImmunoScore™, which received FDA De Novo marketing authorization.
Integrates with hospital EHR systems to support early identification of sepsis risk.
Expanding into broader acute-care and precision-medicine applications using its underlying biomarker-driven platform.
Focused on detection and confirmation and does not appear to integrate workflows into the EHR that drives Sep-1or CMS care elements.

IntelliSep (Cytovale), TriVerity (Inflammatix), Palantir, and IVD Capsule

Represent diagnostic and testing-based approaches that confirm or assess sepsis risk.
Typically requires other clinical decision tools to validate or supplement real-time alerts.
Focused on detection and confirmation and does not appear to integrate workflows into the EHR that drives Sep-1or CMS care elements.

How Do the Top Sepsis Detection Tools Compare?

The following table compares the leading sepsis detection platforms based on key criteria, including regulatory certifications, integration depth, and real-world adoption. This quick reference highlights how each tool supports early detection and compliance management.

Feature	Ambient Sepsis DART	Bayesian Health	The EHR
Sepsis Bundle Compliance	Real-time automated tracking within EHR workflows	Alert-only. Limited compliance visibility	Basic SIRS-based alerts. No bundle-compliance automation
EHR Integration	Deep integration with Epic, Cerner, and Meditech	Limited integration	Native to platform, but not specialized for sepsis workflows
Primary Focus	Detection, workflow, and compliance support	Predictive AI detection	Centralized documentation and data collection
Market Adoption	Deployed in major hospital systems	Early-stage	Universal adoption as part of hospital EHR infrastructure
Clinical Results	Proven improvements in bundle compliance and outcomes	Promising but unproven	Limited impact on SEP-1 adherence over the last decade, often requires add-on tools

Why Do Hospitals Choose Ambient Clinical?

Hospitals selecting sepsis detection technology are increasingly focused on complete solutions, tools that don’t just detect, but also helps clinicians gain efficiency, document, and comply with sepsis care standards.

Ambient Sepsis DART™ brings together advanced analytics, clinical decision support, and automated compliance tracking with EHR and communication platform (Vocera, Zebra, Tiger, Spok, etc..) integration into a single integrated platform. Built for both enterprise and individual hospital use, it supports faster response times, reduces variability, and enables consistent delivery of evidence-based care.

By aligning technology with clinical workflow, Ambient helps hospitals and health systems exceed CMS compliance to avoid Value Based Purchasing penalties, improve patient outcomes, reduce risk, and drive measurable performance improvements across their entire organization.

Conclusion

As hospitals continue to modernize sepsis detection, the most effective solutions are those that integrate clinical insight, regulatory reliability, and real-time workflow support. From AI-driven prediction to comprehensive decision support, the market is advancing rapidly toward data-informed care. Among these innovations, platforms like Ambient Sepsis DART™ demonstrate how evidence-based design and seamless EHR integration can help healthcare teams improve outcomes and strengthen the sepsis response system-wide.